abstract：:Wilson's disease is a rare inherited disorder of copper metabolism, manifesting hepatic, neurological and psychiatric symptoms. Early diagnosis is often unfeasible and a unique diagnostic test is currently inapplicable. We performed the qualitative/quantitative characterization of the salivary proteome/peptidome of 32...

journal_title：Journal of proteomics

authors： Cabras T,Sanna M,Manconi B,Fanni D,Demelia L,Sorbello O,Iavarone F,Castagnola M,Faa G,Messana I

更新日期：2015-10-14 00:00:00

abstract：UNLABELLED:In this study, new angiotensin-I converting enzyme (ACE) inhibitory peptides were comprehensively identified from a thermolysin digest of bitter melon (Momordica charantia) seed proteins. The hydrolysate was fractionated by reversed-phase high performance liquid chromatography (RP-HPLC), and the inhibitory a...

journal_title：Journal of proteomics

authors： Priyanto AD,Doerksen RJ,Chang CI,Sung WC,Widjanarko SB,Kusnadi J,Lin YC,Wang TC,Hsu JL

更新日期：2015-10-14 00:00:00

abstract：:Plasma membrane intrinsic proteins (PIPs) are one subfamily of aquaporins that mediate the transmembrane transport of water. To reveal their function in poplar, we generated transgenic poplar plants in which the translation of PIP genes was downregulated by RNA interference investigated these plants with a comprehensi...

journal_title：Journal of proteomics

authors： Bi Z,Merl-Pham J,Uehlein N,Zimmer I,Mühlhans S,Aichler M,Walch AK,Kaldenhoff R,Palme K,Schnitzler JP,Block K

更新日期：2015-10-14 00:00:00

abstract：UNLABELLED:Acute intermittent porphyria (AIP) is an autosomal dominant metabolic disorder caused by a deficiency of hepatic porphobilinogen deaminase (PBGD). The disease is characterized by life threatening acute neurovisceral attacks. The aim of this study was to identify metabolites secreted by the hepatocytes that r...

journal_title：Journal of proteomics

authors： Serrano-Mendioroz I,Sampedro A,Mora MI,Mauleón I,Segura V,Enríquez de Salamanca R,Harper P,Sardh E,Corrales FJ,Fontanellas A

更新日期：2015-09-08 00:00:00

abstract：:The association of gender with the treatment outcome during long-term antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected patients has been controversial. Here, we performed a comparative proteomic analysis of peripheral blood mononuclear cells (PBMC) by using a label-free shotgun method with n...

journal_title：Journal of proteomics

authors： Zhang L,Wang Z,Chen Y,Zhang C,Xie S,Cui Y,Wang Z

更新日期：2015-08-03 00:00:00

abstract：:Sperm is an ideal model for studying post-translational modifications since its transcriptional and translational activities are nearly silent. Thus, sperm functions are mainly regulated at the protein level, especially by means of post-translational modifications. Published proteomic datasets may contain valuable und...

journal_title：Journal of proteomics

authors： Zhou T,Xia X,Liu J,Wang G,Guo Y,Guo X,Wang X,Sha J

更新日期：2015-08-03 00:00:00

abstract：:A targeted quantitative proteomic investigation employing the multiple reaction monitoring (MRM, SRM) technique was conducted on strawberry fruit at different development stages. We investigated 22 proteins and isoforms from 32 peptides with 111 peptide transitions, which may be involved in the volatile aroma biosynth...

journal_title：Journal of proteomics

authors： Song J,Du L,Li L,Palmer LC,Forney CF,Fillmore S,Zhang Z,Li X

更新日期：2015-08-03 00:00:00

abstract：:Hand, foot and mouth disease is mainly caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16), but EV-A71 is also associated with severe neurological complications. Host factors may contribute to the different clinical outcomes of EV-A71 and CV-A16 infections. A neurovirulent EV-A71 strain (EV-A71/UH1) fro...

journal_title：Journal of proteomics

authors： Chan SY,Sam IC,Lai JK,Chan YF

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:Breast cancer is the principal cancer in women worldwide. Although there are serum tumor markers such as CEA and HER2, they are detected in advanced stages of the disease and used as progression and recurrence markers. Therefore, there is a necessity for the identification of new markers that might lead to a...

journal_title：Journal of proteomics

authors： Calderón-González KG,Valero Rustarazo ML,Labra-Barrios ML,Bazán-Méndez CI,Tavera-Tapia A,Herrera-Aguirre ME,Sánchez del Pino MM,Gallegos-Pérez JL,González-Márquez H,Hernández-Hernández JM,León-Ávila G,Rodríguez-Cuevas S,Guisa-Hoh

更新日期：2015-06-21 00:00:00

abstract：UNLABELLED:The aim of this study was to search for immunogenic schistosomula proteins in the hope of identifying novel intervention targets. Schistosomula proteins were analyzed by immunoproteomic which the probes were sera derived from BALB/c mice (susceptible hosts) and Microtus fortis (resistant hosts). A total of 1...

journal_title：Journal of proteomics

authors： Hong Y,Zhang M,Yang J,Cao X,Han Q,Han Y,Qiu C,Zhu C,Lu K,Li H,Fu Z,Lin J

更新日期：2015-06-21 00:00:00

abstract：UNLABELLED:The pathogenicity of Yersinia enterocolitica biovar 1A strains is controversial as these lack most of the known virulence factors. Acquisition of iron and presence of well-regulated iron homeostasis in bacteria represents an important virulence trait. Differential abundance of proteins was examined under iro...

journal_title：Journal of proteomics

authors： Kanaujia PK,Bajaj P,Kumar S,Singhal N,Virdi JS

更新日期：2015-06-21 00:00:00

abstract：UNLABELLED:Clostridium difficile spores are considered the morphotype of infection, transmission and persistence of C. difficile infections. There is a lack of information on the composition of the outermost exosporium layer of C. difficile spores. Using recently developed exosporium removal methods combined with MS/MS...

journal_title：Journal of proteomics

authors： Díaz-González F,Milano M,Olguin-Araneda V,Pizarro-Cerda J,Castro-Córdova P,Tzeng SC,Maier CS,Sarker MR,Paredes-Sabja D

更新日期：2015-06-18 00:00:00

abstract：UNLABELLED:The membrane-associated LonB protease is essential for viability in Haloferax volcanii, however, the cellular processes affected by this protease in archaea are unknown. In this study, the impact of a lon conditional mutation (down-regulation) on H. volcanii physiology was examined by comparing proteomes of ...

journal_title：Journal of proteomics

authors： Cerletti M,Paggi RA,Guevara CR,Poetsch A,De Castro RE

更新日期：2015-05-21 00:00:00

abstract：UNLABELLED:Inhibition of the essential chaperone Hsp90 with drugs causes a global perturbation of protein folding and the depletion of direct substrates of Hsp90, also called clients. Ubiquitination and proteasomal degradation play a key role in cellular stress responses, but the impact of Hsp90 inhibition on the ubiqu...

journal_title：Journal of proteomics

authors： Quadroni M,Potts A,Waridel P

更新日期：2015-04-29 00:00:00

abstract：UNLABELLED:Karrikins are butenolide plant growth regulators in smoke from burning plant material that have proven ability to promote germination and seedling photomorphogenesis. However, the molecular mechanisms underlying these processes are unclear. Here we provide the first proteome-wide analysis of early responses ...

journal_title：Journal of proteomics

authors： Baldrianová J,Černý M,Novák J,Jedelský PL,Divíšková E,Brzobohatý B

更新日期：2015-04-29 00:00:00

abstract：UNLABELLED:Aspergillus sp. plays an essential role in lignocellulosic biomass recycling and is also exploited as cell factories for the production of industrial enzymes. This study profiled the secretome of Aspergillus fumigatus when grown with cellulose, xylan and starch by high throughput quantitative proteomics usin...

journal_title：Journal of proteomics

authors： Adav SS,Ravindran A,Sze SK

更新日期：2015-04-24 00:00:00

abstract：UNLABELLED:High-throughput molecular analysis is challenging in a non-model species. Proteomics has a great potential to characterize non-model species. We went beyond the level of simply 'identifying' the proteins of interest during osmotic stress experiments in an allopolyploid crop (in casu banana) and focus on an i...

journal_title：Journal of proteomics

authors： Vanhove AC,Vermaelen W,Swennen R,Carpentier SC

更新日期：2015-04-24 00:00:00

abstract：UNLABELLED:Mapping protein-protein interactions for chromatin-associated proteins remains challenging. Here we explore the use of BioID, a proximity biotinylation approach in which a mutated biotin ligase (BirA*) is fused to a bait of interest, allowing for the local activation of biotin and subsequent biotinylation of...

journal_title：Journal of proteomics

authors： Lambert JP,Tucholska M,Go C,Knight JD,Gingras AC

更新日期：2015-04-06 00:00:00

abstract：UNLABELLED:Protein precipitation with organic solvent is an effective means of depleting contaminants such as sodium dodecyl sulfate (SDS), while maintaining high analyte recovery. Here, we report the use of a disposable two-stage spin cartridge to facilitate isolation of the precipitated protein, with subsequent enzym...

journal_title：Journal of proteomics

authors： Crowell AM,MacLellan DL,Doucette AA

更新日期：2015-04-06 00:00:00

abstract：UNLABELLED:The archetypical venomous lizard species are the helodermatids, the gila monsters (Heloderma suspectum) and the beaded lizards (Heloderma horridum). In the present study, the gila monster venom proteome was characterized using 2D-gel electrophoresis and tandem mass spectrometry-based de novo peptide sequenci...

journal_title：Journal of proteomics

authors： Sanggaard KW,Dyrlund TF,Thomsen LR,Nielsen TA,Brøndum L,Wang T,Thøgersen IB,Enghild JJ

更新日期：2015-03-18 00:00:00

abstract：UNLABELLED:Peritoneal dialysis effluent (PDE) is a fluid resulting from the close contact of peritoneal dialysis (PD) solutions with the peritoneal membrane (PM) and represents a readily available material for the search of biomarkers of PM function or damage. Our laboratory has developed a method for the in-depth prot...

journal_title：Journal of proteomics

authors： Bruschi M,Candiano G,Santucci L,D'Ambrosio C,Scaloni A,Bonsano M,Ghiggeri GM,Verrina E

更新日期：2015-02-26 00:00:00

abstract：UNLABELLED:Venoms of the viperid sister genera Eristicophis and Pseudocerastes are poorly studied despite their anecdotal reputation for producing severe or even lethal envenomations. This is due in part to the remote and politically unstable regions that they occupy. All species contained are sit and wait ambush feede...

journal_title：Journal of proteomics

authors： Ali SA,Jackson TN,Casewell NR,Low DH,Rossi S,Baumann K,Fathinia B,Visser J,Nouwens A,Hendrikx I,Jones A,Undheim E,Fry BG

更新日期：2015-02-26 00:00:00

abstract：UNLABELLED:Mutations in the Kit receptor tyrosine kinase gene (KIT), which result in constitutive activation of the protein (KIT), are causally related to the development of gastrointestinal stromal tumors (GISTs). Imatinib, a targeted anticancer drug, exerts a therapeutic effect against GISTs by repressing the kinase ...

journal_title：Journal of proteomics

authors： Nagata K,Kawakami T,Kurata Y,Kimura Y,Suzuki Y,Nagata T,Sakuma Y,Miyagi Y,Hirano H

更新日期：2015-02-06 00:00:00

abstract：UNLABELLED:The 14-3-3 proteins are a group of regulatory proteins of divergent functions in plants. However, little is known about their roles in maize kernel development. Using publically available gene expression profiling data, we found that two 14-3-3 species genes, zmgf14-4 and zmgf14-6, exhibited prominent expres...

journal_title：Journal of proteomics

authors： Dou Y,Liu X,Yin Y,Han S,Lu Y,Liu Y,Hao D

更新日期：2015-01-30 00:00:00

abstract：UNLABELLED:Schistosomiasis is a disease caused by blood trematodes affecting man and animals that represents an important human health and veterinary problem. Main damages caused by this infection are a consequence of the host inflammatory reaction against the parasite eggs trapped inside the liver. Despite that the he...

journal_title：Journal of proteomics

authors： de la Torre-Escudero E,Pérez-Sánchez R,Manzano-Román R,Oleaga A

更新日期：2015-01-30 00:00:00

abstract：UNLABELLED:Isotopic labeling and isobaric labeling are two kinds of the typical quantification method that have been widely used in proteomics analysis. Herein, a novel quantitative strategy, partially isobaric peptide termini labeling (PITL), was developed to overcome the drawbacks of each above-mentioned labeling str...

journal_title：Journal of proteomics

authors： Zhang S,Wu Q,Shan Y,Zhou Y,Zhang L,Zhang Y

更新日期：2015-01-30 00:00:00

abstract：:The Caatinga lancehead, Bothrops erythromelas, is a medically relevant species, responsible for most of the snakebite accidents in most parts of its distribution range in northeastern Brazil. The spectrum and geographic variability of its venom toxins were investigated applying a venomics approach to venom pools from ...

journal_title：Journal of proteomics

authors： Jorge RJ,Monteiro HS,Gonçalves-Machado L,Guarnieri MC,Ximenes RM,Borges-Nojosa DM,Luna KP,Zingali RB,Corrêa-Netto C,Gutiérrez JM,Sanz L,Calvete JJ,Pla D

更新日期：2015-01-30 00:00:00

abstract：UNLABELLED:The 26S proteasome is a proteolytic enzyme found in both cytoplasm and nucleus. In this study, we examined the differential expression of proteasome inhibitor bortezomib-induced proteins in p53-deficient 4T1 cells. It was found that GRP78 and TCEB2 were over-expressed in response to treatment with bortezomib...

journal_title：Journal of proteomics

authors： Yerlikaya A,Okur E,Baykal AT,Acılan C,Boyacı I,Ulukaya E

更新日期：2015-01-15 00:00:00

abstract：:Calcium enhances salt stress tolerance of soybeans. Nevertheless, the molecular mechanism of calcium's involvement in resistance to salt stress is unclear. A comparative proteomic approach was used to investigate protein profiles in germinating soybeans under NaCl-CaCl2 and NaCl-LaCl3 treatments. A total of 80 protein...

journal_title：Journal of proteomics

authors： Yin Y,Yang R,Han Y,Gu Z

更新日期：2015-01-15 00:00:00

abstract：UNLABELLED:Understanding of the avian male gamete biology is essential to improve the conservation of genetic resources and performance in farming. In this study, the chicken semen peptidome/proteome and the molecular phenotype related to sperm quality were investigated. Spermatozoa (SPZ) and corresponding seminal plas...

journal_title：Journal of proteomics

authors： Labas V,Grasseau I,Cahier K,Gargaros A,Harichaux G,Teixeira-Gomes AP,Alves S,Bourin M,Gérard N,Blesbois E

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The highly conserved molecular chaperones Hsp90 and Hsp70 are indispensible for folding and maturation of a significant fraction of the proteome, including many proteins involved in signal transduction and stress response. To examine the dynamics of chaperone-client interactions after DNA damage, we applied ...

journal_title：Journal of proteomics

authors： Truman AW,Kristjansdottir K,Wolfgeher D,Ricco N,Mayampurath A,Volchenboum SL,Clotet J,Kron SJ

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:It is currently unknown how many proteins can be detected in urine. Improving the analytical approach would increase their number and potentially strengthen their predictive potential in diseases. We developed a combination of analytical procedures for maximizing sensitivity and reproducibility of normal hum...

journal_title：Journal of proteomics

authors： Santucci L,Candiano G,Petretto A,Bruschi M,Lavarello C,Inglese E,Righetti PG,Ghiggeri GM

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Saccharomyces cerevisiae is considered a safe microorganism widely used as a dietary supplement. However, in the latest decades several cases of S. cerevisiae infections have been reported. Recent studies in a murine model of systemic infection have also revealed the virulence of some S. cerevisiae dietary s...

journal_title：Journal of proteomics

authors： Hernández-Haro C,Llopis S,Molina M,Monteoliva L,Gil C

更新日期：2015-01-01 00:00:00

abstract：:The human papillomavirus type 16 (HPV-16) E6/E7 spliced transcripts are heterogeneously expressed in cervical carcinoma. The heterogeneity of the E6/E7 splicing profile might be in part due to the intrinsic variation of splicing factors in tumor cells. However, the splicing factors that bind the E6/E7 intron 1 (In-1) ...

journal_title：Journal of proteomics

authors： Martínez-Salazar M,López-Urrutia E,Arechaga-Ocampo E,Bonilla-Moreno R,Martínez-Castillo M,Díaz-Hernández J,Del Moral-Hernández O,Cedillo-Barrón L,Martines-Juarez V,De Nova-Ocampo M,Valdes J,Berumen J,Villegas-Sepúlveda N

更新日期：2014-12-05 00:00:00

abstract：UNLABELLED:Human amoebiasis is an intestinal disease with a global distribution. Due to reports of parasite resistance or susceptibility reduction to metronidazole treatment, there is a renewed interest for the search of new molecules with antiamoebic activity. The flavonoid (-)-epicatechin that was isolated from the M...

journal_title：Journal of proteomics

authors： Bolaños V,Díaz-Martínez A,Soto J,Rodríguez MA,López-Camarillo C,Marchat LA,Ramírez-Moreno E

更新日期：2014-12-05 00:00:00

abstract：UNLABELLED:SKIP and BIR are evolutionarily conserved proteins; SKIP (SKP-1) is a known transcription and splicing cofactor while BIR-1/Survivin regulates cell division, gene expression and development. Their loss of function induces overlapping developmental phenotypes. We searched for SKP-1 and BIR-1 interaction on pr...

journal_title：Journal of proteomics

authors： Kostrouch D,Kostrouchová M,Yilma P,Chughtai AA,Novotný JP,Novák P,Kostrouchová V,Kostrouchová M,Kostrouch Z

更新日期：2014-10-14 00:00:00

abstract：UNLABELLED:We present a combined proteomic and bioinformatic investigation of mitochondrial proteins from the amoeboid protist Acanthamoeba castellanii, the first such comprehensive investigation in a free-living member of the supergroup Amoebozoa. This protist was chosen both for its phylogenetic position (as a sister...

journal_title：Journal of proteomics

authors： Gawryluk RM,Chisholm KA,Pinto DM,Gray MW

更新日期：2014-09-23 00:00:00

abstract：UNLABELLED:Serine/threonine protein phosphatase 1 regulatory subunit 12A (PPP1R12A) modulates the activity and specificity of the catalytic subunit of protein phosphatase 1, regulating various cellular processes via dephosphorylation. Nonetheless, little is known about phosphorylation events controlled by PPP1R12A in s...

journal_title：Journal of proteomics

authors： Zhang X,Ma D,Caruso M,Lewis M,Qi Y,Yi Z

更新日期：2014-09-23 00:00:00

abstract：UNLABELLED:The mechanisms underlying resistance to challenge by gastrointestinal nematode parasites in sheep are complex. Using DIGE, we profiled ovine lymph proteins in lambs with host resistance (R), resilience (Ri) or susceptibility (S) to a daily trickle challenge with the nematode Trichostrongylus colubriformis. E...

journal_title：Journal of proteomics

authors： Bond JJ,Pernthaner A,Zhang K,Rosanowski SM,Clerens S,Bisset SA,Sutherland IA,Koolaard JP,Hein WR

更新日期：2014-09-23 00:00:00

abstract：:Knowledge of the accurate copy number of HLA class I presented ligands is important in fundamental and clinical immunology. Currently, the best copy number determinations are based on mass spectrometry, employing single reaction monitoring (SRM) in combination with a known amount of isotopically labeled peptide. The m...

journal_title：Journal of proteomics

authors： Hassan C,Kester MG,Oudgenoeg G,de Ru AH,Janssen GM,Drijfhout JW,Spaapen RM,Jiménez CR,Heemskerk MH,Falkenburg JH,van Veelen PA

更新日期：2014-09-23 00:00:00